Conventional and microwave irradiation technique for the synthesis of some pyrimidine and pyrazoline derivative from 1-{4'-[(4"-methylpiperazinyl)diazenyl] phenyl}-3-(substitutedphenyl)prop-2-en-1-one and studies of their antimicrobial activity

Department of Chemistry, B. K. M. Science College, Valsad-396 001, Gujarat, India
E-mail : bhavana_mistryll@yahoo.co.in
Manuscript received 08 March 2010, revised 21 September 2010, accepted 05 October 2010

A series of compounds namely 6-{4'-((4"-methylpiperazinyl)diazenyl]phenyl}-4-(substitutedphenyl)pyrimidine 2-yl-amide (Ja-j), 3-{4' -[(4" -methylpiperazinyl)diazenyl]phenyl}-5-(substitutedphenyl)pyrazole (4a-j) and 3-{ 4'-((4"methylpiperazinyl) diazenyl]phenyl}-5-(substitutedphenyl)pyrazolecarboxamide (Sa-j) have been prepared by the reaction of chalcone derivative 1-{ 4' -[ ( 4" -methylpiperaziny l)diazenyl] phenyl}-3-(substitutedphenyl)prop· 2-en-1-one (2a-j) with guanidinium nitrate, hydrazine hydrate and semicarbazide hydrochloride respectively. The reactions have been carried out by both microwave and conventional methods. The microwave-assisted reactions are carried out in a "Q-Pro-M-Modified Microwave System". The compounds have been screened for their antimicrobial activities against different microorganisms. The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, ¹H NMR and Mass spectral data.