Meta-GWAS for age-related hearing impairement

The dataset comprises summary statistics from the meta-GWAS of 17 studies on age-related hearing impairement. The dataset accompanies the following paper:

Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in age-related hearing impairment

Please cite the paper if using this dataset.

Phenotype of ARHI was established using ICD diagnoses and self-reported hearing loss. The study comprised 148,152 cases and 575,472 controls or European ancestry. Adult male and female participants were included from the following 17 population-based cohort studies: Age, Genes/Environment Susceptibility - Reykjavik (AGES), the Danish Twin Registry (DTR), the Estonian Genome Center at the University of Tartu (EGCUT), FinnGen, Framingham Heart Study (FHS), Health Aging and Body Composition (HABC), Italian Network of Genetic Isolates - Friuli Venezia Giulia (INGI-FVG), the Rotterdam Study (RS, cohorts 1 - 3), the Salus in Apulia study (SA; formerly known as Great Age study), Screening Across the Lifespan Twin (SALT and SALTY - young), Screening Twin Adults: Genes and Environment (STAGE), TwinsUK, UK Biobank (UKBB), and the Women’s Genome Health Study (WGHS).  

UK Biobank data have been used under project #11516.

Individual GWASs have been QC'd and harmonyzed using EasyQC followed by fixed-effects IVW meta-analysis using METAL. The dataset includes the results of meta-analysis for n = 8,244,938 SNV with MAF >0.001 and present in at least 9 cohorts.

Dataset columns:

SNP, rsID

CHR, chromosome

BP, genomic position (hg19)

Allele1, effect allele

Allele2, other allele

Freq1, mean frequency of Allele1

FreqSE, standard error of Freq1

MinFreq, minimal frequency of Allele1 in the study cohorts

MaxFreq, maximal frequency of Allele1 in the study cohorts

Effect, effect size from the meta-analysis for Allele1

StdErr, standard error of Effect

P.value, corresponding p-value for meta-analysis

Direction, direction of effects in individual studies

HetISq, I² statistic for heterogeneity between studies

HetChiSq, chi² statistic for heterogeneity between studies

HetDf, degrees of freedom for the chi² statistic

HetPval, p-value for heterogeneity between studies

N, summary sample size

Dataset columns description:

Seventeen studies included: