Published December 5, 2021 | Version v1
Journal article Open

Melatonin Affects Gene Expression of Noradrenaline Transporter and Enzymes in the Hearts of Stressed Rats

Creators

  • 1. Laboratory of Molecular Biology and Endocrinology, Vinča Institute of Nuclear Sciences, the National Institute of the Republic of Serbia, University of Belgrade
  • 2. CEDARS-SINAI, Centre for Neural Science and Medicine, 8700 Beverly Blvd., Los Angeles, CA 90048, USA
  • 3. Laboratory of Molecular Biology and Endocrinology, Vinča Institute of Nuclear Sciences, the National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovića Alasa 12-14, 11351 Belgrade, Serbia
  • 4. Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Nis, Višegradska 33, 18000 Niš, Serbia
  • 5. Laboratory of Molecular Biology and Endocrinology, Vinča Institute of Nuclear Sciences, the National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovića Alasa 12-14, 11351 Belgrade, Serbi

Description

The role of stress is important in the etiology of depression which subsequently
affects cardiovascular regulation. There has been a lot of evidence of the
beneficial effects of melatonin in various cardiovascular pathologies. We
examined the effect of chronic melatonin treatment on noradrenaline content,
synthesis, transport and degradation in the left atria and ventricle of rats
exposed to chronic mild unpredictable stress (CUMS). Our results show
that CUMS decreased expression of mRNA TH and NET in the left atria
and COMT in the left ventricles, whereas increased MAO-A enzymes in the
left ventricles. Melatonin treatment induced a significant increase in gene
expression of NET in the atria and a decrease in MAO-A in the ventricle.
The observed beneficial effects of enhanced uptake and reduced degradation
during melatonin treatment were most probably a compensatory mechanism
which protects cardiomyocytes from the deleterious effects of noradrenaline
overstimulation.
 

Files

01 Stefanovic et al.pdf

Files (725.4 kB)

Name Size Download all
md5:4880e3d72935cea0cf57629882fe379c
725.4 kB Preview Download