Effects Of Marijuana On Serum Calcium, Phosphate And Uric Acid Biochemistry Of Adult Albino Wistar Rat

Marijuana also called weed, herb, pot, grass, bud, ganja, Mary Jane, and a vast number of other slang terms is a greenish-gray mixture of the dried, shredded leaves and flowers of Cannabis sativa the hemp plant. The aim of the study is to investigate the effect of marijuana on the calcium, phosphate and uric acid of adult albino wistar rat. A total of twenty four (24) Albino wistar rats were used. The rats were divided into four groups with six rats each as follows: Group A (control: only feed with normal feed for the same number of days); Group B (0.3ml marijuana + feed); Group C (0.6ml of marijuana + feed); Group D (0.9ml marijuana + feed) for 21 days. Blood specimen were collected into lithium heparin containers, plasma was separated and used for the estimation of calcium, phosphate and uric acid spectrophotometrically. We observe an increase in calcium levels of group B (8.93 ± 0.45), group C (9.77 ± 1.16), group D (10.53 ± 0.74) when compared with the control (8.22 ± 0.44). There was an increase in phosphate levels of group B (4.85 ± 0.39), group C (5.25 ± 0.39), group D (5.60 ± 0.43) when compared to the control (4.36 ± 0.31). There was also an increase in uric acid levels of group B (6.11 ± 0.49), group C (8.02 ± 0.24), group D (9.89 ± 0.94) compared to control (5.07 ± 0.36). There was an increase in weight of the different rats after experiment compared to the weight before the experiment. Conclusively, increasing dosage of marijuana had a high effect on calcium, phosphate and uric acid level of albino wistar rat.0