Dataset Open Access

Genotyping and phenotyping data for Genome-wide analyses of body fat reserves in ewes

Hazard Dominique; Macé Tiphaine; Foulquié Didier; Carrière Fabien; Pradel Julien; Durand Christian; Douls Sébastien; Parisot Sara; González-García Eliel

Among the adaptive capacities of animals, the management of energetic body reserves (BR) through the BR mobilization and accretion processes (BR dynamics, BRD) has become an increasingly valuable attribute for livestock sustainability, allowing animals to cope with more variable environments. BRD has previously been reported to be heritable in ruminants. In the present study, we conducted genome-wide studies (GWAS) in sheep to determine genetic variants associated with BRD. BR levels and BR changes over time were obtained through body condition score measurements at eight physiological stages throughout each productive cycle in Romane ewes (n=1034) and were used as phenotypes for GWAS. After quality controls and imputation, 48,513 single nucleotide polymorphisms (SNP) were included in the GWAS. Among the QTLs identified, a major QTL associated with BR levels during pregnancy and lactation was identified on chromosome 1. In this region, several significant SNPs mapped to the leptin receptor gene (LEPR), among which one SNP mapped to the coding sequence. The point mutation induces the p.P1019S substitution in the cytoplasmic domain, close to tyrosine phosphorylation sites. The frequency of the SNP associated with increased BR levels was 32%, and the LEPR genotype explained up to 5% of the variance of the trait. These results provide strong evidence for involvement of LEPR in the regulation of BRD in sheep and highlight it as a major candidate for improving adaptive capacities.

Data files are provided in Plink format ( https://www.cog-genomics.org/plink).
Files (177.8 MB)
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Romane_INRAE_BRD.bim
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Romane_INRAE_BRD.fam
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Romane_INRAE_BRD_BCS-L.bed
md5:c499c83ec48bffc6695f3fbfec48a4e6
12.6 MB Download
Romane_INRAE_BRD_BCS-L_Sa.bed
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Romane_INRAE_BRD_BCS-M.bed
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Romane_INRAE_BRD_BCS-M_Pa.bed
md5:c499c83ec48bffc6695f3fbfec48a4e6
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Romane_INRAE_BRD_BCS-Pa.bed
md5:c499c83ec48bffc6695f3fbfec48a4e6
12.6 MB Download
Romane_INRAE_BRD_BCS-Pa_L.bed
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12.6 MB Download
Romane_INRAE_BRD_BCS-Pa_W.bed
md5:c499c83ec48bffc6695f3fbfec48a4e6
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Romane_INRAE_BRD_BCS-Pb.bed
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Romane_INRAE_BRD_BCS-Sa.bed
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12.6 MB Download
Romane_INRAE_BRD_BCS-Sb.bed
md5:c499c83ec48bffc6695f3fbfec48a4e6
12.6 MB Download
Romane_INRAE_BRD_BCS-W.bed
md5:c499c83ec48bffc6695f3fbfec48a4e6
12.6 MB Download
Romane_INRAE_BRD_BCS-W_M.bed
md5:c499c83ec48bffc6695f3fbfec48a4e6
12.6 MB Download
Romane_INRAE_BRD_BCS-W_Wp.bed
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12.6 MB Download
Romane_INRAE_BRD_BCS-Wp.bed
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