Acute Portal Vein, Superior Mesenteric Vein andSplenic Vein Thrombosis Secondary toJAK2 V617 Mutation-A Case Report
Creators
- 1. MD Anaesthesia, Senior resident, Department of critical care, Ananthapuri hospital and research institute, Trivandrum, India.
- 2. MD Anaesthesia, DA,DNB anaesthesia, MNAMS, Head of Department, critical care, Ananthapuri hospital and research institute, Trivandrum, India.
- 3. MD Anaesthesia, DA( Anaesthesia), FNB(critical care), Senior Consultant, Dept of critical care, Ananthapuri hospital and research institute, Trivandrum, India.
- 4. MD (General medicine), MRCP (UK), DM (gastro), FRCP( EDIN), Consultant, Dept of gastroenterology, Ananthapuri hospital and research institute, Trivandrum, India.
- 5. MD Anaesthesia, IDCCM, Consultant, Dept of critical care, Ananthapuri hospital and research institute, Trivandrum, India.
- 6. DNB (EM), Consultant, Dept of critical care, Ananthapuri hospital and research institute, Trivandrum, India.
Description
Portal vein thrombosis (PVT) is a rare finding which usually occurs in association with local factors such as cirrhosis, malignancy, pancreatitis, intraabdominal infections or systemic hypercoagulable states. It may present acutely as abdominal pain, ascites, fever or exist in a chronic state which is generally asymptomatic and an incidental finding. With advancement in Imaging and laboratory studies, PVT cases are diagnosed more frequently along with its predisposing factors. The invention of JAK2 mutation and it’s addition to the WHO criteria for Myeloproliferative neoplasm (MPN) diagnosis, has increased the number of MPN cases which were previously labelled idiopathic. We present a case of 54 year old female diagnosed with unprovoked PVT with bowel ischemia and JAK 2 mutation positive, managed surgically and with long term anticoagulation
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