Published November 15, 2021 | Version v1
Journal article Open

Dataset for "Rapid saliva infrared spectroscopy analysis provides snapshot of physiological response to COVID-19: comprehensive in vitro, mouse and cohort studies with meta-analysis"

  • 1. Precision & Systems Biomedicine Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD, Australia 4006
  • 2. 2Biostatistics Unit, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD, Australia 4006
  • 3. Inflammation Biology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD, Australia 4006
  • 4. New South Wales Health Pathology-Royal Prince Alfred Hospital, Camperdown, NSW, Australia 2050
  • 5. Agilent Technologies Australia, Mulgrave, VIC, Australia 3170
  • 6. Lung Inflammation & Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD, Australia 4006, and The Prince Charles Hospital, Brisbane, Australia

Description

ATR-FTIR spectra was acquired to detect and inspect physiological response to SARS-CoV-2 infection from saliva samples. Three experimental models were used to determine robustness of the technique.

In vitro experiment tested supernatant derived from SARS-CoV-2 infected, UV-inactivated SARS-CoV-2 infected, or media control Vero cells. Supernatant collected at 24hr and 48hr post-infection. Data related to Figure 1.

Mouse experiment tested oral lavage from mice exposed to SARS-CoV-2 or UV-inactivated SARS-CoV-2 virus. Lavage collected at 0, 2 and 4 days post-infection. Data related to Figure 2.

Human experiment tested saliva collected at three different sites (NSW, TPCH, QIMR). Patients were tested for SARS-CoV-2 by gold standard PCR methods to determine infection status. PCR results and FTIR spectra included. Data related to Figure 3 and 4.

Notes

This data is uploaded to support a submitted manuscript. Publication DOI to follow once accepted.

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