Journal article Open Access

Dataset for "Rapid saliva infrared spectroscopy analysis provides snapshot of physiological response to COVID-19: comprehensive in vitro, mouse and cohort studies with meta-analysis"

Seth Kazmer; Harley Robinson; Gunter Hartel; Renee S. Richards; Kexin Yan; Sebastiaan J. Van Hal; Raymond Chan; Andrew Hind; David Bradley; Fabian Zieschang; David J. Rawle; Thuy T. Le; David W. Reid; Andreas Suhrbier; Michelle M. Hill

ATR-FTIR spectra was acquired to detect and inspect physiological response to SARS-CoV-2 infection from saliva samples. Three experimental models were used to determine robustness of the technique.

In vitro experiment tested supernatant derived from SARS-CoV-2 infected, UV-inactivated SARS-CoV-2 infected, or media control Vero cells. Supernatant collected at 24hr and 48hr post-infection. Data related to Figure 1.

Mouse experiment tested oral lavage from mice exposed to SARS-CoV-2 or UV-inactivated SARS-CoV-2 virus. Lavage collected at 0, 2 and 4 days post-infection. Data related to Figure 2.

Human experiment tested saliva collected at three different sites (NSW, TPCH, QIMR). Patients were tested for SARS-CoV-2 by gold standard PCR methods to determine infection status. PCR results and FTIR spectra included. Data related to Figure 3 and 4.

This data is uploaded to support a submitted manuscript. Publication DOI to follow once accepted.
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Human_clinical_and_PCR_data.xlsx
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Human_SpectralData.csv
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Mouse_SpectralData.csv
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