PHYTOCHEMICAL INVESTIGATIONS AND PHARMACOLOGICAL EVALUATION OF Mimusopselengi L. BARK FOR HEPATOPROTECTIVE ACTIVITY

The present study includes phytochemical and pharmacological evaluation of bark. Here the powdered bark was subjected to successive soxhlet extraction using different solvents of increasing polarity. Medicinal herb is considered to be a chemical factory as it contains multitude of chemical compounds like alkaloids, glycosides, saponins, resins, oleoresins, sesquiterpene lactones and oils (essential and fixed). Today there is growing interest in chemical composition of plant-based medicines. Several bioactive constituents have been isolated and studied for pharmacological activity. Bark of MimusopselengiL. is an evergreen tree, belonging to family Sapotaceae, cultivated in gardens as an ornamental tree. It is traditionally used as cardiotonic, anthelmintic, in the treatment of leprosy and various ailments. The successive methanol and aqueous extracts were subjected for In-vivo hepatoprotective evaluation. The methanolic extract was found more effective. So it was further subjected for preliminary phytochemical and chromatographic examination. Attempt was made to isolate the compounds using isocratic elution technique.

Keywords: Elution, Hebalism, Herb, Metabolites, Diagnostic