Synthesis, characterization and antifungal activity of thiosemicarbazides and thiosemicarbazones

Department of Chemistry, Punjab Agricultural University, Ludhiana-141 004, Punjab, India
E-mail : joshisukesha@gmail.com, geetu2487@yahoo.com
Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana-141 004, Punjab, India
E-mail : sunita_sharma@pau.edu
Manuscript received online 02 June 2016, accepted 24 September 2016

Thiosemicarbazides (1, 2 and 3) were synthesized by reacting aniline with carbon disulfide followed by addition of hydrazine or phenyl hydrazine or 2,4-dinitrophenyl hydrazine respectively. Different substituted benzaldehydes were condensed with 4-phenylthiosemicarbazide to afford respective thiosemicarbazones (4-15). Antifungal activity of the synthesized compounds exhibited that thiosemicarbazides were more effective than thiosemicarbazones against Macrophomina phaseolina and Fusarium moniliforme. All the synthesized compounds registered less activity than bavistin against both fungi at all concentrations.