THE EFFECT OF ANTIULCER ACTIVITY ON RAUWOLFIA SERPENTINE (ROOT)

The aim of the study was to evaluate the effect of antiulcer activity on rauwolfia serpentine (root). Material and Method: ulcer was induced by aspirin induced model in Wister albino mice. The experimental animals were divided into four groups and received subsequent treatment. Aspirin was induced 500mg/kg b.w. in 3 days by oral dose.  Group 1 (control group) received normal saline 10ml/kg body weight for 5 days, group 2(test group) received low dose of rauwolfia serpentine 30mg/kg body weight for 5 days, group 3(test group) received higher dose of rauwolfia serpentine110mg/kg b.w. for 5 days and group 4 (standard group) received pantoprazole 40mg/kg b.w for 3 days. After completion of dose mice were sacrificed by cervical dislocation and stomach were cut from lesser curvature and everted. Result: - The extract of Rauwolfia serpentine (root) is show significant effect on ulcer induced by aspirin induced model. It is an effective antiulcer agent and increase ulcer protection by regeneration of mucosal layer. Rauwolfia Serpentine exhibited protection against characteristics lesion produced by aspirin administration. It is exhibited anti-inflammatory and antiulcerogenic activity.

Keywords: Peptic ulcer, Rauwolfia Serpentine, Aspirin induced ulcer model, Estimation of mucin, Pathophysiology