FORMULATION AND EVALUATION OF TRANSDERMAL THERAPEUTIC SYSTEM FOR DELIVERING NANO SIZED ROSUVASTATIN
Creators
Description
The objective of present study was to formulate and evaluate transdermal patches for delivering nano sized rosuvastatin. As we know that Rosuvastatin belongs to the BCS class II having low solubility and high permeability. It exhibits poor aqueous solubility, high hepatic first-pass metabolism, and oral bioavailability of less than 20% .To overcome such criteria, efforts have been made to improve bioavailability by preparing Nano sized rosuvastatin and delivering it through the transdermal system.
Rosuvastatin was nano sized by preparing nanosuspension, the best one of having the particle size 854nm was selected and fabricated into the transdermal patch. Prepared transdermal patches were evaluated for various physicochemical parameters. The transdermal patches were found to be thin, clear, smooth, uniform, and flexible. From the study, it was concluded that out of various formulations, the P4 formulation was found to be the optimum formulation with 86.01 % drug release within 24 hours.
Keywords: Nanosized, Transdermal Drug Delivery system, Rosuvastatin
Files
04.Manish Tiwari- IAJPS.pdf
Files
(868.9 kB)
Name | Size | Download all |
---|---|---|
md5:f4272fc191b553ef1d271a7c1221201a
|
868.9 kB | Preview Download |