Description of invariant NKT cells

Karwicka Katarzyna, Szudy-Szczyrek Aneta, Hus Marek. Description of invariant NKT cells. Journal of Education, Health and Sport. 2021;11(9):417-422. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.09.053

https://apcz.umk.pl/JEHS/article/view/JEHS.2021.11.09.053

https://zenodo.org/record/5520106

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Received: 15.09.2021. Revised: 21.09.2021. Accepted: 22.09.2021.

Description of invariant NKT cells

Katarzyna Karwicka, Aneta Szudy-Szczyrek, Marek Hus

Katarzyna Karwicka https://orcid.org/0000-0003-0542-5991 katarzyna.karwicka2@gmail.com

Uniwersytet Medyczny w Lublinie

Poland

Aneta Szudy-Szczyrek https://orcid.org/0000-0003-2352-394X

anetaszudy@gmail.com

Uniwersytet Medyczny w Lublinie

Poland

Marek Hus https://orcid.org/0000-0002-9036-6625

markhus@o2.pl

Uwersytet Medyczny w Lublinie

Poland

Abstract

Recently discovered subpopulations belonging to cell groups called “invariant” NKT, also referred to as type I NKT or classical NKT cells, appear to have a unique impact on the tumor microenvironment. Considering the characteristics of secreted cytokines, production of chemokines and the capability of cell cytotoxic activity, these cells have a significant function in being immune to bacteria, parasites, viruses, autoimmune and tumor diseases. The profile of secreted cytokine is probably decisive in reference to the distinct functions of the subpopulation, some of them exhibit immunosuppressive activity inhibiting an anticancer immune response, and the other stimulate the organisms for eradicating the tumor. Currently, it has been discovered six fundamental, functionally distinct subpopulations of iNKT cells (NKT1, NKT2, NKT10, NKT17, NKTreg, NKT_FH).

Key words: tumor microenvironment; invariant natural killer T cells; iNKT; tumor; immunology; cytokines