"EVALUATION OF ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF CRUDE EXTRACT OF LEAVES OF ASCLEPIAS CURASSAVICA L"

The present research work was aimed to investigate anti-inflammatory and analgesic activity of ethanolic extract of Asclepias curassavica L (EEAC) against Formalin Induced Paw licking, Tail Immersion test, Acetic acid writhing model, carrageenan-induced paw edema method, Egg Albumin-Induced Inflammation EEAC showed significant inhibition in the early phase compared to a late phase in Formalin Induced Paw licking and in Tail Immersion test EEAC at 500mg/kg produced highly significant and greater analgesic activity and in Acetic acid writhing model EEAC at dose 500mg/kg has shown significant reduction in several writing’s. In the carrageenan-induced paw edema method, EEAC produced a significant reduction in paw volume in the 4^th hour, and in Egg albumin-induced inflammation showed significant inhibition in paw volume in the 4^th hour respectively. The mean reaction time, percentage of early and late phases, and the number of writhing were measured. The paw volume was measured using a Digital plethysmometer well as Egg Albumin-Induced Inflammation. However, the present study did not include the tests for establishing the extract mechanism of action.

Keywords: Asclepias curassavica L; Anti-inflammatory; Analgesic; Carrageenan; Indomethacin.