Pleiotropic effects of vitamin D3

Egierska Dominika, Pietruszka Paulina, Burzyńska Paulina, Chruścicka Izabela, Buchta Justyna. Pleiotropic effects of vitamin D3. Journal of Education, Health and Sport. 2021;11(7):143-155. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.07.013

https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.07.013

https://zenodo.org/record/5118429

 

 

 

 

 

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© The Authors 2021;

This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland

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Received: 05.07.2021. Revised: 20.07.2021. Accepted: 21.07.2021.

 

 

 

 

 

Pleiotropic effects of vitamin D3

 

Dominika Egierska

Affiliation Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

Country Poland

Bio Statement —

Principal contact for editorial correspondence.

 

Paulina Pietruszka

Affiliation Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

Country Poland

Bio Statement —

 

Paulina Burzyńska

Affiliation Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

Country Poland

Bio Statement —

 

Izabela Chruścicka

Affiliation Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

Country Poland

Bio Statement —

 

Justyna Buchta

Affiliation Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

Country Poland

Bio Statement —

 

 

Abstract

Introduction: Vitamin D belongs to the group of fat-soluble vitamins. cholecalciferol (D3) and ergocalciferol (D2) are the most important forms. Vitamin D is associated with a regulatory role in calcium and phosphate metabolism. In recent years, there has been attention to its pleiotropic action.

Aim: The aim of the study was to present the general characteristics of vitamin D and explore its relation with polycystic ovary syndrome (PCOS), endometriosis, pain management, insulin resistance, influenza and chronic kidney disease (CKD).

Description: VDR receptor has been detected in the cells of the intestines, bones, kidneys, heart, brain, prostate, breast, ovaries, skin. In the ovaries, vit. D3 affects the production of progesterone, estradiol or estrone which suggest its important role in the folliculogenesis and ovulation. Women with PCOS have significantly lower levels of vitamin D3 compared to healthy women. It has been suggested that the deficiency of this vitamin may be related to infertility. Research show that vit. D3 may affect the mechanisms of the inflammatory and nocyceptive pain perception. A significant connection has also been found between vit. D3 and the metabolism of the adipose tissue and insulin secretion. Vitamin D3 deficiency may increase the risk of development of obesity and insulin resistance as well as CKD.

Summary: The observation of statistically significant correlation between the reduced level of vit. D3 and occurrence of numerous diseases indicates the need for further research to explain the mechanisms in which D3 deficiency may contribute to development of these diseases. This knowledge is important for the development of new prevention and treatment methods of the diseases mentioned in this article.

 

Key words: Vitamin D3; cholecalciferol; calcitriol