Published April 15, 2016
| Version v1
Journal article
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RUNNING HEAD: GLIABLASTOME MULTIFORME THE EFFECTIVENES OF HYPERBARIC OXYGEN THERAPY AND SOROFENIB IN AN ESTABLISHED INTRACEREBRAL TUMOR MODEL IN RATS USING THE C6 GLIAL CELL
Creators
- 1. Department of Neurosurgery, BezmialemVakıf University, School of Medicine, Istanbul, Turkey.
- 2. Special Medok Hyperbaric Oxygen Therapy Center, Istanbul, Turkey.
- 3. Department of Physiotherapy, Istanbul University, Institute of Cardiology, Istanbul, Turkey.
- 4. Department of Hyperbaric Oxygen Therapy, İstanbul University, School of Medicine, Istanbul, Turkey
- 5. Departmant of Histology and Embiyology, Zirve University School of Medicine, Gaziantep, Turkey
Description
Gliomas are the most common brain tumour in adults. Glioblastoma (GBM) is a type of tumor that is highly lethal despite maximal therapy. Tumor-related endothelial cells are of neoplastic nature and have malignant properties such as proliferation and invasion. Therefore, antiangiogenic approaches have several advantages compared with conventional chemotherapeutic approaches. This study was undertaken to investigate the preventive or therapeutic effect of hyperbaric oxygen therapy (HBOT) in an established intracerebral tumor model. In this regard, parameters such as the tumor size, vascularization rate, midkine (MK), nuclear factor kappa B (NF-kB), HIF-1 alpha, and caspase 3 were compared in the relevant groups.
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