Cytotoxic triterpenoids and triterpene sugar esters from the medicinal mushroom Fomitopsis betulina
Creators
- 1. University of Belgrade, Faculty of Chemistry, Studentski trg 12-16, 11000, Belgrade, Serbia
- 2. University of Belgrade, Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, Studentski trg 12-16, 11000, Belgrade, Serbia
- 3. Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000, Belgrade, Serbia
- 4. University of Belgrade, Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, Studentski trg 12-16, 11000, Belgrade, Serbia email: mironov@chem.bg.ac.rs
- 5. University of Belgrade, Faculty of Chemistry, Studentski trg 12-16, 11000, Belgrade, Serbia; Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000, Belgrade, Serbia
Description
Thirteen undescribed 24-methylene lanostane triterpenoids, named polyporenic acids E-M and fomitosides L-O, as well as seventeen known analogues, were isolated from the fruiting bodies of the mushroom Fomitopsis betulina. Their structures were determined using 1D, 2D NMR, IR, and HRESIMS. Fomitoside L and fomitoside N exhibited cytotoxicity against HL60 leukemia cells (IC50 = 15.8 and 23.7 μM, respectively). Among the known compounds, notable cytotoxicities against HL60 leukemia cells and selectivity with respect to MRC-5 healthy cells were noticed for dehydropachymic acid (IC50 = 10.9 μM, SI 8.6), pachymic acid (IC50 = 11.0 μM, SI 9.8), 3-epi-dehydrotumulosic acid (IC50 = 19.9 μM, SI 5.8) and 12α-hydroxy-3α-(3′-hydroxy-4′-methoxycarbonyl-3′-methylbutyryloxy)-24-methyllanosta-8,24 (31)-dien-26-oic acid (IC50 = 19.2 μM, SI 2.2).
Graphical abstract
https://ars.els-cdn.com/content/image/1-s2.0-S003194222031195X-fx1_lrg.jpg
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Additional details
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- Is part of
- 0031-9422 (ISSN)
Funding
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination 172053
- Ministry of Education, Science and Technological Development
- Biological response modifiers in physiological and pathological conditions 175011
- Ministry of Education, Science and Technological Development