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Published May 16, 2017 | Version v1
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Data from: Association between the severity of influenza A(H7N9) virus infections and length of the incubation period

Creators

  • 1. University of Hong Kong
  • 2. Chinese Center For Disease Control and Prevention

Description

Background: In early 2013, a novel avian-origin influenza A(H7N9) virus emerged in China, and has caused sporadic human infections. The incubation period is the delay from infection until onset of symptoms, and varies from person to person. Few previous studies have examined whether the duration of the incubation period correlates with subsequent disease severity. Methods and Findings: We analyzed data of period of exposure on 395 human cases of laboratory-confirmed influenza A(H7N9) virus infection in China in a Bayesian framework using a Weibull distribution. We found a longer incubation period for the 173 fatal cases with a mean of 3.7 days (95% credibility interval, CrI: 3.4–4.1), compared to a mean of 3.3 days (95% CrI: 2.9–3.6) for the 222 non-fatal cases, and the difference in means was marginally significant at 0.47 days (95% CrI: -0.04, 0.99). There was a statistically significant correlation between a longer incubation period and an increased risk of death after adjustment for age, sex, geographical location and underlying medical conditions (adjusted odds ratio 1.70 per day increase in incubation period; 95% credibility interval 1.47–1.97). Conclusions: We found a significant association between a longer incubation period and a greater risk of death among human H7N9 cases. The underlying biological mechanisms leading to this association deserve further exploration.

Notes

Read me (data file explanations)
Data on H7N9 cases in China
This data file contains information on 395 human cases of laboratory-confirmed H7N9 infection in China between Mar 2013 and Aug 2014.
data_h7n9_severity.csv
Simple MCMC function scripts
R syntax to define the MCMC functions to be used in other scripts
mcmc_function_incubation.r
Table 1 scripts
Table_1.r
Table 2 scripts
Table_2.r
Table 3 scripts
Table_3.r
Table 4 scripts
Table_4.r
Figure 1 scripts
Figure_1.r
Figure 2 scripts
Figure_2.r

Files

data_h7n9_severity.csv

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Additional details

Related works

Is cited by
10.1371/journal.pone.0148506 (DOI)