Dryad
Published September 1, 2016 | Version v1
Dataset Open

Data from: Stable recombination hotspots in birds

Creators

  • 1. Columbia University
  • 2. University of Chicago
  • 3. Wellcome Centre for Human Genetics
  • 4. Beijing Genomics Institute
  • 5. University of California, Santa Cruz
  • 6. East Carolina University
  • 7. Macquarie University

Description

The DNA-binding protein PRDM9 has a critical role in specifying meiotic recombination hotspots in mice and apes, but it appears to be absent from other vertebrate species, including birds. To study the evolution and determinants of recombination in species lacking the gene that encodes PRDM9, we inferred fine-scale genetic maps from population resequencing data for two bird species: the zebra finch, Taeniopygia guttata, and the long-tailed finch, Poephila acuticauda. We found that both species have recombination hotspots, which are enriched near functional genomic elements. Unlike in mice and apes, most hotspots are shared between the two species, and their conservation seems to extend over tens of millions of years. These observations suggest that in the absence of PRDM9, recombination targets functional features that both enable access to the genome and constrain its evolution.

Notes

Genomes & recombination maps for zebra finch and long-tailed finch
DataDryad.zip

Files

DataDryad.zip

Files (801.9 MB)

Name Size Download all
md5:d53d063d4b5f36e657278e460e463b92
801.9 MB Preview Download
md5:eb1c3b520509ddcb7308111c6cdfb132
1.7 kB Preview Download

Additional details

Related works

Is cited by
10.1126/science.aad0843 (DOI)