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Published February 22, 2021 | Version v1
Preprint Open

Fetal heart rate and nuchal translucency as first trimester markers of preterm birth

Authors/Creators

  • 1. Servicio de Obstetricia y Ginecología, Hospital Universitario y Politécnico La Fe, Valencia, Spain; Departamento de Pediatría, Obstetricia y Ginecología, Universidad de Valencia, Valencia, Spain
  • 2. Servicio de Obstetricia y Ginecología, Hospital Universitario y Politécnico La Fe, Valencia, Spain
  • 3. Servicio de Obstetricia y Ginecología, Hospital Francisco de Borja, Gandía, Valencia, Spain
  • 4. Servicio de Obstetricia y Ginecología, Hospital Universitario y Politécnico La Fe, Valencia, Spain; Departamento de Pediatría, Obstetricia y Ginecología, Universidad de Valencia, Valencia, Spain

Description

Objective

To evaluate whether first trimester fetal heart rate (FHR) and nuchal translucency (NT) associate with preterm birth (PTB).

Methods

This was a comparative case-control study of 518 normal pregnancies with no history of PTB of which 272 delivered at term (TB) and 246 progressed to spontaneous PTB prior to 37, 34, 32 and 28 weeks. Fetal heart rate (FHR) and nuchal translucency (NT) values at the first trimester scan were compared by means of univariable (Mann-Whitney) and multivariable logistic regression analysis considering hourglass membranes (HM) as the most severe PTB subgroup. Finally severity trends for both parameters were investigated using correlations with gestational age (GA) at delivery and Kruskal-Walls tests.

Results

Regardless of GA at delivery, pregnancies affected with PTB showed higher FHR and thicker NT at the first trimester scan. The association was confirmed by the multivariable analysis and the severity trends, which paired the highest FHR and NT values with the most severe cases of PTB (p<0.001) (p<0.0001).

Conclusion

Fetuses with subsequent late, early and very early PTB show higher values of NT and FHR at the first trimester scan.

Notes

This is an Author's Original Manuscript of an article published by Taylor & Francis in Journal of Maternal-Fetal and Neonatal Medicine on 22 February 2021, available at http://wwww.tandfonline.com/10.1080/14767058.2021.1887128. Funding sources: Gabriela Loscalzo received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant, agreement No 765274.

Files

Manuscript Morales-Rosello J Matern Fetal Neonatal Med 2021.pdf

Files (192.7 kB)

Additional details

Funding

European Commission
iPLACENTA - Innovation in modelling Placenta for Maternal and Fetal Health 765274