Data from: Large scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine
Creators
- Onderwater, Gerrit L.J.1
- Ligthart, Lannie2
- Bot, Mariska
- Demirkan, Ayse1
- Fu, Jingyuan3
- van der Kallen, Carla J.H.
- Vijfhuizen, Lisanne S.1
- Pool, René2
- Liu, Jun4
- Vanmolkot, Floris H.M.5
- Beekman, Marian6
- Wen, Hoyan
- Amin, Najaf4
- Thesing, Carisha S.6
- Pijpers, Judith A.1
- Kies, Dennis A.1
- Zielman, Ronald1
- de Boer, Irene
- van Greevenbroek, Marleen M.J.
- Arts, Ilja C.W.7
- Milaneschi, Yuri6
- Schram, Miranda T.7
- Dagnelie, Pieter C.7
- Franke, Lude3
- Ikram, M. Arfan8
- Ferrari, Michel D.1
- Goeman, Jelle J.1
- Slagboom, P. Eline1
- Wijmenga, Cisca3
- Stehouwer, Coen D.A.7
- Boomsma, Dorret I.9
- van Duijn, Cornelia M.
- Penninx, Brenda W.6
- 't Hoen, Peter A.C.
- Terwindt, Gisela M.1
- van den Maagdenberg, Arn M.J.M.
- 1. Leiden University Medical Center
- 2. VU University Amsterdam
- 3. University Medical Center Groningen
- 4. Departments of Epidemiology and Neurology, Erasmus Medical Centre, Rotterdam*
- 5. Maastricht University Medical Centre
- 6. VU University Medical Center
- 7. Maastricht University
- 8. Erasmus University Medical Center
- 9. Amsterdam Neuroscience
Description
Objective: To identify a plasma metabolomic biomarker signature for migraine. Methods: Plasma samples from 8 Dutch cohorts (n = 10,153: 2,800 migraine patients and 7,353 controls) were profiled on a 1H-NMR-based metabolomics platform, to quantify 146 individual metabolites (e.g., lipids, fatty acids, and lipoproteins) and 79 metabolite ratios. Metabolite measures associated with migraine were obtained after single-metabolite logistic regression combined with a random-effects meta-analysis performed in a nonstratified and sex-stratified manner. Next, a global test analysis was performed to identify sets of related metabolites associated with migraine. The Holm procedure was applied to control the family-wise error rate at 5% in single-metabolite and global test analyses. Results: Decreases in the level of apolipoprotein A1 (β −0.10; 95% confidence interval [CI] −0.16, −0.05; adjusted p = 0.029) and free cholesterol to total lipid ratio present in small high-density lipoprotein subspecies (HDL) (β −0.10; 95% CI −0.15, −0.05; adjusted p = 0.029) were associated with migraine status. In addition, only in male participants, a decreased level of omega-3 fatty acids (β −0.24; 95% CI −0.36, −0.12; adjusted p = 0.033) was associated with migraine. Global test analysis further supported that HDL traits (but not other lipoproteins) were associated with migraine status. Conclusions: Metabolic profiling of plasma yielded alterations in HDL metabolism in migraine patients and decreased omega-3 fatty acids only in male migraineurs.
Notes
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Additional details
Related works
- Is cited by
- 10.1212/wnl.0000000000007313 (DOI)