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Published September 1, 2017 | Version v1
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Data from: The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea

Creators

  • 1. University of Basel
  • 2. Walter and Eliza Hall Institute of Medical Research
  • 3. Papua New Guinea Institute of Medical Research
  • 4. University of Melbourne

Description

The molecular force of blood-stage infection (molFOB) is a quantitative surrogate metric for malaria transmission at population level and for exposure at individual level. Relationships between molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax (Pv) hypnozoites were eliminated in half the children by primaquine (PQ). Discounting relapses, children acquired equal numbers of new P. falciparum (Pf) and Pv blood-stage infections/year (Pf-molFOB=0-18, Pv-molFOB=0-23) resulting in comparable spatial and temporal patterns in incidence and prevalence of infections. Including relapses, Pv-molFOB increased >3-fold (relative to PQ-treated children) showing greater heterogeneity at individual (Pv-molFOB=0-36) and village levels. Pf- and Pv-molFOB were strongly associated with clinical episode risk. Yearly Pf clinical incidence rate (IR=0.28) was higher than for Pv (IR=0.12) despite lower Pf-molFOB. These relationships between molFOB, clinical incidence and parasite prevalence reveal a comparable decline in Pf and Pv transmission that is normally hidden by the high burden of Pv relapses.

Notes

Albinama_eLife_Database
Data from: The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea.

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Related works

Is cited by
10.7554/elife.23708 (DOI)