Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine.

Experimental data from

Modeling Na_V1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration
dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic
migraine.

Louisiane Lemaire^1,2,*, Mathieu Desroches^1,2, Martin Krupa^1,3, Lara Pizzamiglio_5,6, Paolo
Scalmani⁴, Massimo Mantegazza^5,6,7,**

1 Inria Sophia Antipolis Méditerranée Research Centre, MathNeuro Team, Valbonne-Sophia Antipolis,
France.
2 Université Côte d’Azur, Nice, France.
3 Université Côte d’Azur, Laboratoire Jean-Alexandre Dieudonné, Nice, France.
4 U.O. VII Clinical and Experimental Epileptology, Foundation IRCCS Neurological Institute Carlo
Besta, Milan, Italy.
5 Université Côte d’Azur, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia
Antipolis, France.
6 CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis,
France.
7 Inserm, Valbonne-Sophia Antipolis, France.

Corresponding authors:
*  louisiane.lemaire@inria.fr
** mantegazza@ipmc.cnrs.fr

https://hal.archives-ouvertes.fr/hal-03191275