Published July 18, 2021 | Version v1
Journal article Open

Plantas medicinales y compuestos puros con efecto protector ante el daño hepático que provoca el metotrexato: Revisión bibliográfica

Creators

  • 1. Unidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social. Ciudad de México, México.

Description

RESUMEN

La hepatotoxicidad es el principal efecto secundario que provoca el metotrexato, fármaco muy utilizado para tratar enfermedades autoinmunes, tumores malignos, cáncer, psoriasis, asma, artritis reumatoide (AR), lupus, embarazo ectópico, leucemia y otros padecimientos. En los últimos años se están realizando investigaciones in vivo enfocadas a la búsqueda de agentes hepatoprotectores que ayuden a disminuir el daño causado por este fármaco. Este trabajo está enfocado a describir el efecto hepatoprotector de algunos compuestos sintéticos y naturales (carvacrol, floridzina, berberina, pentoxifilina, ácido clorogénico, ácido gálico, resveratrol, licopeno, carvacrol, ácido alfa lipoico, ozono y melatonina); así como los extractos orgánicos de plantas medicinales (Curcuma longa, Sphaeralcea angustifolia, Balanites aegyptica, Morus nigra, Spinacea oleracea y el propóleo) que previenen y/o protegen al hígado del daño causado por el metotrexato. La mayoría de estas evaluaciones han sido realizados en modelos in vivo, empleando ratas principalmente.

 

 

ABSTRACT

Hepatotoxicity is the main side effect caused by methotrexate, a drug widely used to treat autoimmune diseases, malignant tumors, cancer, psoriasis, asthma, rheumatoid arthritis (RA), lupus, ectopic pregnancy, leukemia and for other diseases. In recent years, in vivo research has been carried out focused on the search for hepatoprotective agents that help reduce the damage caused by this drug.

This review is focused on describing the hepatoprotective effect of some synthetic and natural compounds (carvacrol, floridzine, berberine, pentoxifylline, chlorogenic acid, gallic acid, resveratrol, lycopene, carvacrol, alpha lipoic acid, ozone and melatonin); as well as organic extracts from medicinal plants (Curcuma longa, Sphaeralcea angustifolia, Balanites aegyptica, Morus nigra, Spinacea oleracea and propolis) that prevent and/or protect the liver from damage caused by methotrexate. Most of these evaluations have been carried out in in vivo models, mainly using rats.

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