Journal article Open Access

Studying genotoxic and antimutagenic effects of plant extracts in Drosophila test systems

Stamenković-Radak Marina; Andjelković Marko

To gain more information on biological effects of plants, particularly herbs used in human medicine
and diet, in vitro and in vivo methods have been developed to predict their genotoxicity and/
or antigenotoxicity in various test systems. The sex-linked recessive lethal (SLRL) and somatic
mutations and recombination (SMART) tests are in vivo assays on D. melanogaster that have been
used to test both mutagenic and antigenotoxic effects of extracts from numerous plant species
used worldwide. The similarity of metabolic pathways between Drosophila and mammals and the
ability to activate promutagens make the results of these tests widely applicable. Besides, Drosophila
presents significant orthology with human genes that control cancers, which makes the assays on
Drosophila reliable and informative for extrapolations onto humans.


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