Laboratórna Diagnostika
Published May 22, 2021 | Version v1
Journal article Open

Vybrané hematologické parametre počas hypolipidemickej liečby

Creators

  • 1. I. interná klinika LF UK a UNB, Bratislava; VITACARE, s. r. o., všeobecná ambulancia pre dospelých, Senec

Description

SÚHRN

Kvantitatívne a kvalitatívne zmeny lipoproteínov v plazme v prospech aterogénnych častíc významne ovplyvňujú kardiovaskulárne (KV) riziko. Cieľom prezentovanej práce bolo objasniť súvislosť lipoproteínových subpopulácií vo vzťahu k strednému objemu trombocytov (MPV) a k distribučnej šírke erytrocytov (RDW). Vyšetrili sme 80 pacientov s dyslipidémiou (z toho 58 žien, priemerný vek súboru 61 rokov), bez predchádzajúcej hypolipemickej liečby. Liečení boli atorvastatínom 40 mg počas troch mesiacov. Pred liečbou a po 12 týždňoch liečby bol vyšetrený celkový cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), triacylglyceroly (TAG), LDL-subfrakcie (veľké LDL častice 1–2 a malé denzné (sd)-LDL častice 3–7), apolipoproteíny (apoA1, apoB), pomer apoB/apoA1, aterogénny index plazmy (AIP), hematologické parametre (vrátane MPV, RDW) a bezpečnostné parametre (obličkové, pečeňové). Hematologické parametre (MPV a RDW) na začiatku liečby signifikantne korelovali s aterogénnymi ukazovateľmi (LDL 3–7, ApoB, ApoB/ApoA1, AIP. Po dvanástich týždňoch atorvastatínovej liečby hladiny MPV a RDW signifikantne klesli súbežne s hladinami lipidov, pričom v skupine s najvýznamnejším poklesom aterogénnych lipoproteínov poklesli tiež. Možno predpokladať, že hladiny MPV a RDW odrážajú proaterogénny lipoproteínový profil reprezentovaný prítomnosťou malých denzných LDL častíc.

ABSTRACT

Quantitative and qualitative changes in plasma lipoproteins mainly atherogenic particles can significantly affect the cardiovascular risk. The aim of the present study was to analyze the relation of lipoprotein subpopulations to mean platelet volume (MPV) and erythrocyte distribution width (RDW). Patients (n = 80) with dyslipidemia (58 females, mean age 61 years), without previous hypolipemic treatment, were treated with atorvastatin 40 mg/day for 3 months. Total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density cholesterol (HDL-C), triglycerides (TAG), LDL-C sub-fractions [large LDL-C 1—2 and small dense (sd)-LDL-C 3—7], apolipoproteins (apoA1, apoB), apoB/apoA1 ratio, atherogenic index of plasma (AIP), haematological parameters (including MPV, RDW) and safety parameters (renal, hepatic) were measured before and after 12 weeks of atorvastatin treatment. Haematological parameters (MPV and RDW) at the baseline of treatment significantly correlated with atherogenic markers (LDL 3—7, ApoB, ApoB/ApoA1, AIP). After 12 weeks of treatment with atorvastatin, MPV and RDW values underwent significant modification simultaneously with other lipids and also in those patients displaying the strongest atherogenic-lowering effect. Values of MPV and RDW seem to reflect a pro-atherogenic lipoprotein profile mainly represented by the presence of sd-LDL-C.

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