AN OVERVIEW OF ARTIFICIAL SKIN

Background: The skin is a multifunctional organ that is protective, self-healing and capable of sensing and many forms of artificial skins have been developed with properties and functionalities approximating those of natural skin.

Objective: Objective of this review article is about the different materials used for the preparation of artificial skin, skin grafting, skin bioprinting and manufacturing process of artificial skin.

Study Selection: In bioengineering process, the production of artificial skin substitute is increases gradually and at the same time the synthesis of keratinocytes by in vitro culture also. Artificial skin came to include products used for the clinical treatment of acute and chronic wounds as well as laboratory models for the study of the basic biology of the skin.

Methods and Materials: Different Biomaterials used in the preparation of Artificial Skin such as Collagen, PLGA, glucophage, Bovine type 1 collagen, HA, Chitosan. Two manufacturing process are commonly used, they are Mesh Scaffolding Method and Collagen Method.

Skin Substitutes are classified in to three class such as Temporary and Impervious Dressing Materials, Single Layer Durable Skin Substitutes, Composite Skin Substitutes.

The first-class materials again classified in to two more types such as Single layer materials, Double layer materials produced by tissue engineering. Similarly, second class materials are classified in to epidermal substitutes, dermal substitutes. Class three composite skin substitutes classified in to Human skin substitutes, Produced by tissue engineering.

Conclusion: The main study of this review article, includes the artificial skin technologies are to provide protection from infection, dehydration, and protein loss after severe skin loss or damage.

Keywords: Artificial Skin, Skin Bioprinting, Skin Substitutes, Biomaterials