Single-cell transcriptomics identifies synergistic role of leukemic and non-leukemic immune repertoires in CD8+ T-cell Large Granular Lymphocytic Leukemia
Description
Data to reproduce findings in the manuscript "Single-cell transcriptomics identifies synergistic role of leukemic and non-leukemic immune repertoires in CD8+ T-cell Large Granular Lymphocytic Leukemia".
The folder contains:
1) Processed scRNA+TCRab-seq data in a Seurat-folder, including
* Object with 11 T-LGLL samples and 6 healthy samples
* Object with only hyperexpanded (>= 10 TCRs) T-cells from all T-LGLL samples and 6 healthy samples
* Object with only T-LGLL clones from 11 T-LGLL samples
* Object with non-leukemic repertoires from 11 T-LGLL samples, 6 healthy samples, 4 CML samples, 4 CLL samples, 2 RCC samples, and 1 NSCLC sample
2) TCRb-seq samples from CD8+ sorted peripheral blood samples from patients with CD8+ T-LGLL
Please see manuscript and Github for further details.
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