In vitro antiproliferative and antimicrobial evaluation of the Cu(II) and Co(II) analogous
- 1. Faculty of Pharmacy, Vojvode Stepe 450, 11000 Belgrade
- 2. Higher Medical and Business-technological School of Applied Studies, Hajduk Veljkova 10, 15000 Šabac
- 3. Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade
Description
Two new complexes with the general formula [Cu2(L)tpmc](ClO4)3·nH2O (tpmc = N,N′,N′′,N′′′-tetrakis(2-pyridylmethyl)- -1,4,8,11-tetraazacyclotetradecane, L = N-methylglycine, n = 3; L = N,N- -dimethylglycine, n = 2) were isolated and their composition, some physical and chemical properties and geometries were proposed based on elemental analysis (C, H, N), conductometric and magnetic measurements and spectroscopic data (UV–Vis, FTIR). It is evident that the complexes are binuclear and an exo coordination mode of the macrocyclic ligand in the boat conformation was proposed. The co-ligands are coordinated as a bridge using both oxygen atoms of the OCO- group. The cytotoxic activity of Cu(II) complexes as well as their Co(II) analogs, the starting ligands and the free salts were tested against human cervix adenocarcinoma cell line (HeLa), human chronic myelogenous leukemia cells (K562), human breast cancer cell line (MDA-MB-453), and a non-cancerous cell line, human embryonic lung fibroblast (MRC-5). The IC50 values for the Cu(II) complexes were from 21.6±0.04 to 66.1±0.8, and for the Co(II) analogs were within the range from 8.8±0.74 to 15.40±1.52. All four complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.
Notes
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Synthesis and characterization of copper(II) octaazamacrocyclic. 8438-Article Text-48060-4-10-20200521.pdf
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Related works
- Is derived from
- https://www.shd.org.rs/JSCS/ (URL)
- Is source of
- 0352-5139 (ISSN)
- gnd:1820-7421(Online) (gnd)
Funding
- Design, synthesis, characterization and assessment of practical applications of coordination and organometallic compounds 172014
- Ministry of Education, Science and Technological Development