Published April 7, 2021 | Version 1.0.0
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Enhanced Ca2+ signaling, mild primary aldosteronism, and hypertension in a familial hyperaldosteronism mouse model (Cacna1h M1560V/+)

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Description

This repository contains the calcium imaging data used for the analysis of zona glomerulosa function in the paper. Data are from experiments on acute slice preparations stained with Fura-2 AM or Calbryte 520 AM dyes. The archives contain the data in HDF5 file format as well as analysis scripts in IPython notebook or R format. Please contact gabriel.stoelting<at>charite.de for more information regarding these files or for access to the original TIFF files. The publication may be accessed under https://doi.org/10.1073/pnas.2014876118

 

A description of the file structure and the tools used to generate the HDF5 files can be found in: Schewe, J., Seidel, E., Forslund, S. et al. Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation. Nat Commun 10, 5155 (2019). https://doi.org/10.1038/s41467-019-13033-4

Notes

This work was supported by the Fritz Thyssen Stiftung Grant 10.16.1.027MN (to U.I.S.); the Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen Rückkehrprogramm and Junges Kolleg grants (both to U.I.S.); the Stiftung Charité BIH Johanna Quandt Professorship (U.I.S.); the Deutsche Forschungsgemeinschaft Grant SFB 1365 (to S.K.F., D.N.M., and U.I.S.) and STO 1260/1-1 (to G.S.); the DZHK (German Centre for Cardiovascular Research) (S.K.F.); and the BMBF (German Ministry of Education and Research) (S.K.F.).

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Calbryte 520 AM.zip

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