Dataset relative to article "Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy"
Creators
- Giuseppe Liberatore1
- Claudia Giannotta1
- Blesson Punnen Sajeev1
- Emanuela Morenghi2
- Fabrizia Terenghi1
- Francesca Gallia1
- Pietro Emiliano Doneddu1
- Fiore Manganelli3
- Dario Cocito4
- Massimiliano Filosto5
- Giovanni Antonini6
- Giuseppe Cosentino7
- Girolama Alessandra Marfia8
- Angelo Maurizio Clerici9
- Giuseppe Lauria10
- Tiziana Rosso11
- Guido Cavaletti12
- Eduardo Nobile- Orazio1
- 1. Neuromuscular and Neuroimmunology Service, IRCCS Humanitas Clinical and Research Center, Rozzano, Milan, Italy
- 2. Biostatistics Unit, IRCCS Humanitas Clinical and Research Center, Rozzano, Milan, Italy
- 3. Department of Neuroscience, Reproductive Sciences and Odontostomatology, University of Naples 'Federico II', Naples, Italy
- 4. Presidio Sanitario Major, Istituti Clinici Scientifici Maugeri, Turin, Italy
- 5. Center for Neuromuscular Diseases and Neuropathies, Unit of Neurology, ASST 'Spedali Civili', University of Brescia, Brescia, Italy
- 6. Unit of Neuromuscular Diseases, Department of Neurology Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, 'Sapienza' University of Rome, Sant'Andrea Hospital, Rome, Italy
- 7. Department of Experimental BioMedicine and Clinical Neurosciences (BioNeC), University of Palermo, Palermo, Italy
- 8. Dysimmune Neuropathies Unit, Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy
- 9. Neurology Unit, Circolo & Macchi Foundation Hospital, Insubria University, DBSV, Varese, Italy
- 10. Unit of Neuroalgology, IRCCS Foundation 'Carlo Besta' Neurological Institute, Milan, Italy
- 11. ULSS2 Marca Trevigiana, UOC Neurologia-Castelfranco Veneto, Treviso, Italy
- 12. School of Medicine and Surgery and Experimental Neurology Unit, University of Milano- Bicocca, Monza, Italy
Description
This record contains data related to article “Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy".
Abstract
For the diagnosis of anti-MAG polyneuropathy the commercial ELISA manufacturer currently recommends a cut-off of 1000 Bühlmann Titer Units (BTU). We analyzed sera from 80 anti-MAG neuropathy patients and 383 controls (with other neuropathies or healthy controls) to assess the ELISA sensitivity and specificity at different thresholds. A better combination of sensitivity/specificity was found at a threshold >1500 BTU than at >1000 BTU. The best value of specificity was obtained at threshold >7000 BTU. There was a diagnostic grey area between 1500 and 7000 BTU in which the clinical phenotypes as well as electrophysiological studies need to be carefully assessed particularly to differentiate CIDP and anti-MAG neuropathy.
Files
Restricted
The record is publicly accessible, but files are restricted to users with access.
Additional details
Related works
- Is supplement to
- 10.1016/j.jneuroim.2020.577288 (DOI)
- 32544754 (PMID)