Virtual cohort of 1000 synthetic heart meshes from adult human healthy population

Dataset Description: We present a database of four-chamber heart models derived from a statistical shape model (SSM) suitable for electro-mechanical (EM) simulations. Our database consists of 1000 four-chamber heart models generated from end-diastolic CT-derived meshes (available in the repository called ("Virtual cohort of adult healthy four-chamber heart meshes from CT images"). These meshes were used for EM simulations. The weights of the SSM are also provided.

Cardiac meshes: To build the SSM, we rigidly aligned the CT cohort and extracted the surfaces, representing them asdeRham currents. The registration between meshes and computation of the average shape was done using a Large Deformation Diffeomorphic Metric Mapping method. The deformation functions depend on a set of uniformly distributed control points in which the shapes are embedded, and on the deformation vectors attached to these points. It is in this spatial field of deformation vectors (one per each control point) where the Principal Component Analysis (PCA) is applied. Case #20 of the CT cohort was not included. More information on the details can be found in Supplement 3 of the reference paper. We created this cohort by modifying the weight of the modes explaining 90%of the variance in shape (corresponding to modes 1 to 9) within 2 standard deviations (SD) of each mode added to the average mesh. The elements of all the meshes are labelled as follows:

1. Left ventricle myocardium
2. Right ventricle myocardium
3. Left atrium myocardium
4. Right atrium myocardium
5. Aorta wall
6. Pulmonary artery wall
7. Mitral valve plane
8. Tricuspid valve plane
9. Aortic valve plane
10. Pulmonary valve plane
11. Left atrium appendage "inlet"
12. Left superior pulmonary vein inlet
13. Left inferior pulmonary vein inlet
14. Right inferior pulmonary vein inlet
15. Right superior pulmonary vein inlet
16. Superior vena cava inlet
17. Inferior vena cava inlet
18. Left atrial appendage border
19. Right inferior pulmonary vein border
20. Left inferior pulmonary vein border
21. Left superior pulmonary vein border
22. Right superior pulmonary vein border
23. Superior vena cava border
24. Inferior vena cava border

Each zipped folder contains 25 meshes and the weights of modes used to construct them for each mesh, A VTK file for each mesh  (in ASCII) contains an UNSTRUCTURED GRID with the following fields:

• POINTS, with the coordinates of the points in mm.
• CELL_TYPES, having all of the points the value 10 since they are tetrahedra.
• CELLS, with the indices of the vertices of every element.
• CELL_DATA, corresponding to the meshing tags.

In addition, three descriptive files are included:

• Normalized_explained_variance.csv contains the percentages of variance explained by each of the 18 modes generated from PCA.
• Mode_standard_deviation.csv contains absolute standard deviations of each of the 18 modes.
• Eigenvectors.csv contains the directions of maximum shape variability within the shape population.