Dataset related to article "Hypofractionated Whole Breast Irradiation and Simultaneous Integrated Boost in Large-breasted Patients: Long-term Toxicity and Cosmesis"s
Creators
- De Rose, Fiorenza1
- Fogliata, Antonella1
- Franceschini, Davide1
- Iftode, Cristina1
- D'Agostino, Giuseppe1
- Comito, Tiziana1
- Franzese, Ciro2
- Di Brina, Lucia1
- Clerici, Elena1
- Loi, Mauro1
- Navarria, Pierina1
- Gatzemeier, Wolfgang1
- Testori, Alberto1
- Tinterri, Corrado1
- Lobefalo, Francesca1
- Tomatis, Stefano1
- Cozzi, Luca2
- Scorsetti, Marta2
- 1. Humanitas Research Hospital IRCCS, Rozzano, Italy
- 2. Humanitas Research Hospital IRCCS, Rozzano, Italy AND Humanitas University, Rozzano, Italy
Description
This record contains data related to article "Hypofractionated Whole Breast Irradiation and Simultaneous Integrated Boost in Large-breasted Patients: Long-term Toxicity and Cosmesis"
Abstract
Introduction: The purpose of this study was to evaluate the impact of breast size on long-term toxicity and cosmesis in patients with breast cancer treated with hypofractionated simultaneous integrated boost (SIB) using volumetric modulated arc therapy (VMAT).
Patients and methods: Patients with early stage breast cancer were treated with 3-week hypofractionated SIB-VMAT to the whole breast (40.5 Gy) and tumor bed (48 Gy). Two cohorts were identified: small/medium- (< 1000 cm3) and large- (> 1000 cm3) breasted patients. Acute and late (at 2 and 5 years) skin toxicity and cosmetic data were analyzed. Univariate and multivariate analysis evaluated associations between toxicity and dosimetric/anatomical variables.
Results: From August 2010 to March 2017, a total of 1160 patients were treated; 831 had at least 2 years of follow-up and were analyzed. Treated skin area (TSA) receiving at least 20 Gy > 400 cm2 and V105% of Boost > 5 cm3 were significant predictors for acute skin toxicity. Multivariate analysis at 2 years was significant for boost volume > 70 cm3, TSA > 400 cm2, and breast size > 1500 cm3. At 5 year analysis (352 patients), none of the analyzed variables was significant. For cosmetic outcome, only the breast size (> 1000 cm3) and the boost size > 70 cm3 at 2 and 5 years, respectively, confirmed significance.
Conclusions: The TSA > 400 cm2 resulted as a significant predictor of both acute and late skin toxicity at 2 years; however, at 5 years, no breast size or dosimetric parameter suggested indications for increased toxicity. A worse cosmetic outcome was recorded at the 2-year follow up for large breasts, but was not confirmed at the 5-year follow-up. These long-term data suggest that hypofractionated SIB-VMAT is a viable modality also in large-breasted patients.
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- Is supplement to
- 10.1016/j.clbc.2020.06.005 (DOI)
- 32665192 (ean8)