CORRELATION OF ADIPOCYTOKINES AND OXIDATIVE STRESS IN TYPE 2 DIABETES MELLITUS AND THEIR ASSOCIATION WITH DEGREE OF INSULIN RESISTANCE.

Background and Objectives: Adipocytokines and Oxidative Stress are often studied in relation to various morbidities but whether these two are interrelated in causing insulin resistance in type 2 diabetes mellitus, is controversial. This study explored their association in type 2 diabetes mellitus and correlation with insulin resistance. Methods: 69 male diabetics and 30 age-sex matched non- diabetic control were studied. Fasting blood glucose, serum insulin, leptin, adiponectin and plasma MDA ( Malondealdehyde, marker for Oxidative Stress) were estimated and compared between two groups by unpaired Student’s t – test. Insulin resistance score was calculated by HOMA-IR (Homeostatic Model Assesment- Insulin Resistance) method. Correlation among the parameters was assessed by Pearsons coefficient of correlation (r- value). Results: Diabetics had higher levels of leptin, MDA , leptin- adiponectin ratio but lower adiponectin than non-diabetics. Correlation of MDA was positive with Leptin but inverse with adiponectn. Insulin reistance score was correlated positively with leptin, leptin- adiponectin ratio, MDA but negatively with adiponectin. Interpretation: Study concludes that, Oxidative Stress may lead to over production of leptin and suppress that of adiponectin and thereby result in increased leptin- adiponectin ratio which is a necessary background for insulin resistance. This is how, oxidative stress may have a positive correlation with insulin resistance in type 2 diabetes mellitus.