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Published December 22, 2020 | Version v1
Journal article Open

Consensus Statement for Pharmacological Management of Coronavirus Disease 2019 (COVID-19): A Pragmatic Approach

Creators

  • 1. Consultant Critical Care, Nayati Healthcare, Mathura, Uttar Pradesh, India
  • 2. Head CCM and Emergency Medicine, Regency Super Specialty Hospital, Lucknow, India
  • 3. Specialist and Head Critical Care Medicine, Head -Prevention and Control of Infection, NMC Specialty Hospital, Al Nahda 2, Dubai, UAE
  • 4. Assistant Professor of Anesthesiology, Department Of Anesthesia and Critical Care Medicine, Mayo Clinic, USA
  • 5. Associate Professor, Section Head for Research, Department of Anesthesiology, Wake Forest University School of Medicine, Cleveland, OH, USA
  • 6. Consultant, Head of ICU at Security Forces Hospital, Dammam, Saudi Arabia
  • 7. Director of the Intensive Care Services, Chair Intensive Care Committee, American Hospital Dubai, UAE
  • 8. Head of Critical Care Department, Reliance Hospital, Navi Mumbai, India
  • 9. Associate Director, Institute of Critical Care Medicine, Max Super Specialty Hospital, Saket New Delhi, India
  • 10. The University of Queensland, Australia; Scientific Consultant, Nimes University Hospital, University of Montpellier, France
  • 11. Department of Anaesthesiology, Intensive Care and Pain Medicine, Tan Tock Seng Hospital, Singapore
  • 12. Medicina Intensiva, Coordinador Neuro UCIN, Jefe del Servicio de Cuidados Intermedios, Hospital Nacional Almanzor Aguinaga Asenjo, EsSalud, Perú
  • 13. Prof and Head of Department Neuro Intensive Care Unit, Ruby Hall Clinic, Grant medical Foundation, Pune, India
  • 14. Deputy Director, Head of Regional Vascular Centre, Sklifosovsky Research Institute of Emergency Medicine, Bolshaya Sukharevskaya Square, Russia
  • 15. Professor and Head of Department, Critical Care Medicine, Ziauddin University, Karachi, Pakistan
  • 16. Department Intensive Care Medicine, University Hospital Brussel (UZB), Brussels, Belgium 18Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium
  • 17. Atkinson Morley Regional Neurosciences Centre, St George's Hospital, London, UK
  • 18. Professor, Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
  • 19. Associate Professor, Department of Internal Medicine, Medical İntensive Care Unit, Gazi University Faculty of Medicine, Turkey
  • 20. Clinical Head Adult Multidisciplinary Intensive Care Unit, Department of Medicine, Divisions of Critical Care and Pulmonology, University of the Witwatersrand, Johannesburg, South Africa
  • 21. Professor of Intensive Care Medicine, Director, Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, UK
  • 22. Pulmonologist, Medcare Hospital Sharjah and Dubai London Clinic and Hospital, Dubai, UAE
  • 23. Consultant Intensive Care Physician, Columbia Asia Hospitals, Bangalore, India
  • 24. Professor and Head Department of Anaesthesia and Intensive Care, Rome, Italy; Member of the Board of the FEDERATION EUROPEEN des MEDICINE, Brussels, Belgium; P. Member of the World Commission on Safety and Quality WFSA, WHO; Visiting Professor, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia, Greece; Visiting Professor, Campus Bio Medico University, Rome, Italy
  • 25. Director, Strategy and COVID-19 Management, Yashoda Super Specialty Hospital, Kaushambi, Ghaziabad, UP, India
  • 26. Honorary Consultant Intensivist & Internist, Ahmedabad, India
  • 27. Additional Professor of Anaesthesiology, Critical Care, Pain and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India
  • 28. Senior Consultant Critical Care Medicine, Nayati Healthcare, Mathura, UP, India
  • 29. Pulmonologist, NMC Royal Hospital DIP, Dubai, UAE
  • 30. Clinical Professor of Medicine, UCLA School of Medicine, USA
  • 31. Assistant Professor, Critical Care Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh
  • 32. Clinical Associate Professor, Attending Anesthesiologist and Intensivist, Department of Anesthesiology, National Taiwan University Hospital (NTUH), Taiwan; Chair, Scientific Committee, Taiwan Society of Emergency & Critical Care Medicine (TSECCM), Taiwan; Vice-Chair, Research Committee and International Affairs, TSECCM, Taiwan; Secretary General, Taiwan Society of Critical Care Medicine (TSCCM), Taiwan
  • 33. Hospital Posadas, Buenos Aires, Argentina

Description

Introduction: In the absence of high-quality evidence for Coronavirus disease-2019 (COVID-19), supportive care is advocated during this pandemic. We aim to develop a consensus statement from global experts for pharmacological management, based on the pathophysiology of COVID-19.
Material and Methods: We used a modified Delphi methodology in three steps: 1) Formulation of the steering committee and questionnaire; 2) Delphi methodology and selection of experts; 3) Final meeting of the steering committee and analysis, discussion, preparation, and presentation of captured data.
Results: 34 (73·9%) experts accepted the invitation for the study. We conducted two rounds of Delphi and consensus (>70% votes) was achieved on 11 out of 24 statements after the end of round two.
Conclusion: This global consensus suggests that “Anti-viral therapy should be administered in the early infection phase of COVID-19 followed by low dose steroid therapy in pulmonary phase. Prophylactic dose anticoagulation should be used in hospitalized, mild to moderate COVID-19 patients. We make no suggestions for the use of immune modulation therapy”.

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