THE RELATIONSHIP BETWEEN OXIDATIVE STRESS AND HIGH SENSITIVE C-REACTIVE PROTEIN IN PREECLAMPSIA

Background & Objectives: Preeclampsia, being most common medical complication of pregnancy requires early diagnosis and intervention. The aim of present study is to measure and correlate serum MDA level with HS-CRP level in preeclampsia. Methods: The present study involves 200 subjects in the age group of 20 to 35 years primigravida, all in their third trimester, recruited from preeclampsia ward and OPD of Mahila Chikitsalaya, Sanganeri gate, Jaipur (Rajasthan). Out of total 200 subjects, 100 were preeclampsia women and 100 were normotensive pregnant women. Data were statistically analyzed by “z” test for comparison of mean and Karl Pearson coefficient of correlation to quantify the association between the variables. Results: The levels of serum MDA (nmol/ml) and HS-CRP (mg/l) were significantly elevated (p0.05). Interpretation & Conclusion: Elevated serum MDA and HS-CRP in preeclampsia women compared with normal pregnant women suggests that oxidative stress in preeclampsia is associated with increased inflammatory responses.