Human Brain Project
Published October 13, 2020 | Version v1
Journal article Open

Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1

Creators

  • 1. Department of Biology, SUNY Albany, 1400 Washington Avenue, Albany, NY 12222, USA.
  • 2. Department of Biology, SUNY Albany, 1400 Washington Avenue, Albany, NY 12222, USA; Department of Physics, SUNY Albany, 1400 Washington Avenue, Albany, NY 12222, USA.
  • 3. Department of Biology, SUNY Albany, 1400 Washington Avenue, Albany, NY 12222, USA; Bethlehem Central High School, 700 Delaware Avenue, Delmar, NY 12054, USA.
  • 4. Federal University of São Paulo, Department of Biochemistry, 100 Rua Tres de Maio, São Paulo 04044-020, Brazil; National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
  • 5. Department of Psychology, SUNY Albany, 1400 Washington Avenue, Albany, NY 12222, USA.
  • 6. Institute of Biophysics, National Research Council, 153 Via Ugo La Malfa, Palermo 90146, Italy.
  • 7. Department of Biophysics, Lomonosov Moscow State University, Leninskie Gory 1/12, Moscow 119234, Russia; Department of Molecular Neurobiology, Institute of Bioorganic Chemistry, Ulitsa Miklukho-Maklaya 16/10, Moscow 117997, Russia.
  • 8. National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
  • 9. Department of Physics, SUNY Albany, 1400 Washington Avenue, Albany, NY 12222, USA.
  • 10. Department of Molecular Neurobiology, Institute of Bioorganic Chemistry, Ulitsa Miklukho-Maklaya 16/10, Moscow 117997, Russia; Sechenov First Moscow State Medical University, Bolshaya Pirogovskaya Ulitsa 19с1, Moscow 119146, Russia.

Contributors

Contact person:

  • 1. Department of Biology, SUNY Albany, 1400 Washington Avenue, Albany, NY 12222, USA.

Description

McCauley et al. shed light on the molecular and cellular mechanisms that allow hippocampal neurons and astrocytes to shape circadian changes in synaptic plasticity and hippocampaldependent behaviors. They identify corticosterone as a key molecule mediating these effects, capable of tuning the temporal dynamics of cognitive processing in mice.

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