Journal article Open Access

OXIDATIVE STRESS AS A MARKER OF CARDIOVASCULAR RISK IN CHILDREN ON REGULAR HEMODIALYSIS

Dr Sidra Amin, Dr Ayesha Anwar, Dr Shehla Yousuf

Introduction: Chronic kidney disease (CKD) is associated with a severely increased risk of cardiovascular morbidity and mortality. Numerous structural and functional alterations of the cardiovascular system, e.g. endothelial dysfunction, arterial stiffening, left ventricular hypertrophy (LVH) and remodeling of the vessel wall with hyperplasia and calcification occur early in the course of CKD and contribute to the overt risk of ischemic cardiovascular disease (CVD) and sudden cardiac death. Aims and objectives: The basic aim of the study is to analyze the oxidative stress as a marker of cardiovascular risk in children on regular hemodialysis. Material and methods: This cross sectional study was conducted at Ameer ud din Medical College during 2019. There were 40 children who was selected for this study. At the time of the study, all the patients were on regular three HD sessions per week; each time for 3–4 h for more than 3 months with polysulfone dialyzing membranes, after creatinine clearance had fallen below 8–12 mL/min and/or pharmacological treatment and diet had proved inadequate to control clinical symptoms. Results: We collected all the demographic data of patients. At before-dialysis session, duration of disease positively correlated with HIP-1α (r = 0.677, P <0.001) but negatively correlated with VEGF (r = −0.486, P < 0.001); VEGF positively correlated with each of pyruvate (r = 0.316, P <0.047) and HIF-1α (r = 0.374, P <0.018), and, OSI positively correlated with TPX (r = 0.969, P <0.001), but, negatively correlated with TAC (r = −0.469, P <0.002).

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