Primordial GATA6 macrophages function as extravascular platelets in sterile injury
Creators
- 1. University of Bern
- 2. University of Calgary
- 3. University of Hamburg
Description
Most multicellular organisms have a major body cavity that harbors immune cells. In primordial species like purple sea urchins, these cells perform phagocytic functions but are also crucial in repairing injuries. In mammals, the peritoneal cavity contains large numbers of resident GATA6+ macrophages, which may play a similar role. It is unclear how cavity macrophages suspended in the fluid phase (peritoneal fluid) identify and migrate towards injuries, however. Here, we show that cavity macrophages in fluid rapidly form thrombus-like structures in response to injury using primordial scavenger receptor (SRCR) domains. Aggregates of cavity macrophages physically sealed injuries and promoted rapid repair of focal lesions. In iatrogenic surgical situations, these cavity macrophages formed extensive aggregates that promoted the growth of intra-abdominal scar tissue termed peritoneal adhesions.
Notes
Please start by reading the readme.txt file which contains all necessary information to use this data set.
Funding provided by: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001711
Award Number: SNSF P1BEP3_181164
Funding provided by: Deutsche Forschungsgemeinschaft
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001659
Award Number: DE 2654/1-1
Funding provided by: Deutsche Forschungsgemeinschaft
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001659
Award Number: PE 2737/1-1
Funding provided by: Natural Sciences and Engineering Research Council of Canada
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100000038
Award Number: RGPIN/07191-2019
Funding provided by: Banting Postdoctoral Fellowships*
Crossref Funder Registry ID:
Award Number:
Funding provided by: Canadian Institutes of Health Research
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100000024
Award Number:
Funding provided by: Canadian Institute of Health Research Fellowships*
Crossref Funder Registry ID:
Award Number:
Funding provided by: Banting Postdoctoral Fellowships
Crossref Funder Registry ID:
Funding provided by: Canadian Institute of Health Research Fellowships
Crossref Funder Registry ID:
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Fig1_cell_counts_over_time.csv
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