Relationships between geomagnetic Ар-indeх and parameters of the immunity in patients with multiple sclerosis and radiculopathies

Popovych Igor L., Gozhenko Anatoliy I., Badiuk Nataliya S., Zukow Walery, Yanchij Roman I., Lapovets’ Natalia Ye., Lapovets’ Lyubov Ye., Akimova Viorica M., Nahurna Yaryna V., Martinova Olha I., Vivchar Roman Ya., Chendey Ivanna V., Ruzhylo Sofiya V. Relationships between geomagnetic Ар-indeх and parameters of the immunity in patients with multiple sclerosis and radiculopathies. Preprint. 2020. 1-18. DOI http://dx.doi.org/10.5281/zenodo.4396371

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Relationships between geomagnetic Ар-indeх and parameters of the immunity in patients with multiple sclerosis and radiculopathies

Igor L. Popovych^1,3, Anatoliy I. Gozhenko¹, Nataliya S. Badiuk¹, Walery Zukow², Roman I. Yanchij³, Natalia Ye. Lapovets’⁴, Lyubov Ye. Lapovets’⁴, Viorica M. Akimova⁴, Yaryna V. Nahurna⁴, Olha I. Martinova⁴, Roman Ya. Vivchar⁴, Ivanna V. Chendey⁴, Sofiya V. Ruzhylo⁵

¹State Enterprise Ukrainian Research Institute for Medicine of Transport, Ministry of Health of Ukraine, Odesa, Ukraine prof.gozhenko@gmail.com

²Nicolaus Copernicus University, Torun, Poland w.zukow@wp.pl

³OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine i.popovych@biph.kiev.ua

⁴Danylo Halyts’kyǐ National Medical University, L’viv, Ukraine lapovets@ukr.net

⁵Ivan Franko Pedagogical University, Drohobych, Ukraine doctor-0701@ukr.net

Corresponding Author Walery Zukow w.zukow@wp.pl

Abstract

Background. The effect of geomagnetism on human immunity has so far been studied through long-term observations. We set ourselves the goal of detecting the immediate immunotropic effects of the Earth's magnetic field by analyzing the relationships between immunity parameters and the geomagnetic Ap-index. Material and methods. The object of observation were 74 patients with multiple sclerosis and 14 patients with radiculopathies, who in the period from September 2014 to November 2018 conducted a one-time assessment of immune status by the relative content in the blood of lymphocytes of CD3⁺, CD4⁺, CD8⁺, CD25⁺, CD56⁺ and CD19⁺ phenotypes and serum level of Immunoglobulines M, G, A as well as CIC and IL-1β. On the day of blood capture and during the previous 7 days, retrospectively recorded the geomagnetic Ap-index, using a publicly available information resource http://wdc.kugi.kyoto-u.ac.jp/kp/index.html. Results. During the week, the average level of Ap-index ranged from 12÷20 nT. The correlation coefficients between the Ap-index on the day of blood collection and 1, 3 and 7 days before it and the level of CD3⁺CD4⁺ lymphocytes were -0,57; -0,48; -0,55 і -0,52 respectively, while on other days were in the range of -0,35÷0,05. In contrast, with the level of CD56⁺ lymphocytes Ap-index correlates positively and almost mirror (0,56; 0,43; 0,54 і 0,57 respectively and 0,34÷-0,08), due to the reciprocity of their levels (r=-0,80). Also positive, but much weaker, correlates the Ap-index with the level of CD3⁺CD25⁺ lymphocytes (0,35; 0,25; 0,45 і 0,31 respectively and 0,22÷-0,14). In contrast, with the level of IL-1β Ap-index correlates significantly only on the day of blood collection and 2 days before (r=0,21 and 0,31 respectively), and with other registered parameters of immunity the correlation is insignificant. The canonical correlation between Ap-indices for 7 days before and on the day of blood collection, on the one hand, and the levels of CD4⁺, CD56⁺, CD25⁺ and CD8⁺ lymphocytes and the concentration of IgM and IL-1β - on the other hand, was very strong: R=0,741; R²=0,549; χ²₍₄₂₎=130; p<10^-6. Conclusion. Disturbances of the geomagnetic field (Ap-index) has a significant immediate modulating effect on the level of immune parameters in the blood, mostly T-helpers (suppressor) and natural killers (enhancing).

Key words: geomagnetic Ap-index; immune status; multiple sclerosis; radiculopathy.

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