Published December 23, 2020 | Version 1
Dataset Open

Lactate Increases Stemness of CD8+ T Cells to Augment Anti-Tumor Immunity

Creators

  • 1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
  • 2. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
  • 3. Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
  • 4. Department of Otolaryngology, University of Texas Southwestern Medical Center, Dallas, TX, USA

Contributors

  • 1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
  • 2. Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

Description

The immunological role of lactate in antitumor immunity is not well understood. In this study, we report lactate treatment significantly augments antitumor efficacy of immune checkpoint blockade or T cell vaccine therapy in multiple tumor models. Single cell transcriptomics and flow cytometry analysis revealed an increased subpopulation of stem-like TCF-1-expressing CD8+ T cells upon lactate treatment.

Files

LacTreatmentSC_CellInfo.txt

Files (433.7 MB)

Name Size Download all
md5:8ed0d722ae230f5e9f3f688015bcafd7
912.7 kB Preview Download
md5:21ddf0871fe09c235dbe91e6113471c3
432.8 MB Download