SARS-CoV-2 Inhibition by Sulfonated Compounds
Creators
- 1. EPFL
- 2. IVI
- 3. UniGe
- 4. Unige
Description
Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) depends on angiotensin converting enzyme 2 (ACE2) for cellular entry, but it might also rely on attachment receptors such as heparan sulfates. Several groups have recently demonstrated an affinity of the SARS-CoV2 spike protein for heparan sulfates and a reduced binding to cells in the presence of heparin or heparinase treatment. Here, we investigated the inhibitory activity of several sulfated and sulfonated molecules, which prevent interaction with heparan sulfates, against vesicular stomatitis virus (VSV)-pseudotyped-SARS-CoV-2 and the authentic SARS-CoV-2. Sulfonated cyclodextrins and nanoparticles that have recently shown broad-spectrum non-toxic virucidal activity against many heparan sulfates binding viruses showed inhibitory activity in the micromolar and nanomolar ranges, respectively. In stark contrast with the mechanisms that these compounds present for these other viruses, the inhibition against SARS-CoV-2 was found to be simply reversible.
Files
MG016_1__0000_1.tif
Files
(123.2 MB)
Name | Size | Download all |
---|---|---|
md5:b34f51a7aff07f1e0b3bef6777543844
|
422.7 kB | Download |
md5:3c4aaf8510bb3945e86df93b99a4fc23
|
1.9 MB | Download |
md5:3ebbf84196e347bce4e3fdc81fc7d8b2
|
50.4 kB | Download |
md5:87ad0983d53956902c7809ee46d6e302
|
208.9 kB | Download |
md5:8eee1d48244ebdae9d16626b246b4b6c
|
10.7 MB | Download |
md5:95feabfd9f5f4c85623964730cd234a7
|
10.7 MB | Download |
md5:298f70202d73ebbb8b717c14f2df3a0d
|
2.7 MB | Preview Download |
md5:34c6c03fbc2be2dcc8e8037ce5d4a444
|
10.7 MB | Download |
md5:33e270e39b2539453f7b9c50a81d248c
|
10.7 MB | Download |
md5:cea3955dc087660a16c1965735f62085
|
2.7 MB | Preview Download |
md5:cf6c2fad0af2b13db9d0fae54c53dd9b
|
10.7 MB | Download |
md5:bb8d24e1e28a9ee7a258ea683572a509
|
10.7 MB | Download |
md5:ae179ac503fa21fc0e89598d72de2b97
|
2.7 MB | Preview Download |
md5:eb68ae0f7f22d9dc594c33c7e91e21a9
|
10.7 MB | Download |
md5:945b2db708e063574bfeec441b9ef9a4
|
10.7 MB | Download |
md5:09640e089c9d30bd5677d4fc5c38f995
|
2.7 MB | Preview Download |
md5:1d396fdbfcadcb9f6b93aceb7f07fbe2
|
10.7 MB | Download |
md5:3b03e8bc8aee2bf954456bda1b106f13
|
10.7 MB | Download |
md5:4e6d4789679c0f4e72eeac5500f01434
|
2.7 MB | Preview Download |
md5:3e958d5669ce72c3e9b59795326d8902
|
21.9 kB | Download |
Additional details
Funding
- NCCR Bio-Inspired Materials: Using Concepts from Nature to Create ‚Smart' Materials (phase II) 51NF40-182881
- Swiss National Science Foundation