Data from: Integration of genomics and transcriptomics predicts diabetic retinopathy susceptibility genes
Creators
- 1. Lurie Children's Hospital
- 2. NeoGenomics (United States)
- 3. University of Illinois at Chicago
- 4. University of Chicago
- 5. Johns Hopkins University
- 6. National Eye Institute
- 7. George Washington University
- 8. Northwestern University
Description
We determined differential gene expression in response to high glucose in lymphoblastoid cell lines derived from matched individuals with type 1 diabetes with and without retinopathy. Those genes exhibiting the largest difference in glucose response were assessed for association to diabetic retinopathy in a genome-wide association study meta-analysis. Expression Quantitative Trait Loci (eQTLs) of the glucose response genes were tested for association with diabetic retinopathy. We detected an enrichment of the eQTLs from the glucose response genes among small association p-values and identified FLCN as a susceptibility gene for diabetic retinopathy. Expression of FLCN in response to glucose was greater in individuals with diabetic retinopathy. Independent cohorts of individuals with diabetes revealed an association of FLCN eQTLs to diabetic retinopathy. Mendelian randomization confirmed a direct positive effect of increased FLCN expression on retinopathy. Integrating genetic association with gene expression implicated FLCN as a disease gene for diabetic retinopathy.
Files
Figure_3._Source_data_5.txt
Files
(717.8 MB)
Name | Size | Download all |
---|---|---|
md5:cfe50c6a0ff799049537d6432dc2c3c5
|
116.0 MB | Preview Download |
md5:eecb66d89ae2996d8de3d3b084c2083f
|
601.8 MB | Preview Download |