A REVIEW: REMDESIVIR IS A HOPEFUL AGENT FOR COVID-19

The pandemic COVID-19(Coronavirus disease-19) is an extremely contagious respiratory illness due to novel coronavirus SARS CoV-2. The structure of coronavirus disease -19 has been homogeneous, coronavirus structure consisting of the four structural proteins named S (Spike), E (Envelope), M (Membrane) & N (Nucleocapsid). N protein holds the RNA genome virus & S, E, M protein create virus envelope together. For the time-consuming process to available drug remdesivir used to against covid -19. Different clinical trial of remdesivir effective on the Ebola virus has been demonstrated. Remdesivir may be effective therapy in vitro and animal models infected by SARS and MERS coronavirus. Remdesivir is a phosphoramide pro drug of C-nucleoside. It can enter into the respiratory epithelial cells in humans, the prodrug metabolized to a nucleoside triphosphate as the active form. So much clinical trials were ongoing on COVID-19 in the health sector. In the treatment of COVID-19 with remdesivir is effective in the future along with another combination drug that may effect the treatment of Covid-19.  

Key Words: Coronavirus-19, Remdesivir, COVID-19 Structure, Mode of Action of remdesivir, Clinical trials, Repurpose of Remdesivir, Future Perspective.