Published October 22, 2015
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Synthesis of Novel Quinoline-substituted 1,4-dihydropyridine Derivatives via Hantzsch Reaction in Aqueous Medium: Potential Bioactive Compounds
- 1. Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Vanak, Tehran, Iran.
Description
The synthesis of a novel series of substituted 1,4-dihydropyridines was achieved in aqueous media by base-catalyzed three-component Hantzsch reaction of 2chloroquinoline-3-carbaldehydes, ammonium acetate, and alkyl acteoacetate in good to high yields. Important advantages of this method are easy access to a library of novel quinoline and quinolone derivatives, green reaction conditions with water as solvent, and ease of purification.
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Synthesis of Novel Quinoline-substituted 1,4-dihydropyridine Derivatives via Hantzsch Reaction in Aqueous Medium Potential Bioactive Compounds.pdf
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