Published May 29, 2019
| Version 3
Dataset
Open
Human Galatose-1-phosphate Uridylyltransferase (GALT), Galactokinase 1 (GALK1); A Target Enabling Package
Creators
- 1. Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford
- 2. Department of Nutrition and Integrative Physiology, Pediatric Genetics, University of Utah
- 3. Department of Biochemistry, University of Utah
Description
This project describes a drug discovery plan for Classic Galactosemia, a rare disorder of galactose metabolism where there is currently no disease-transforming therapy. This TEP provides the protein reagents, biophysical assays, and structural information to facilitate two aspects of galactosemia research: (i) to understand the molecular basis of the disease due to defective GALT enzyme, and (ii) to provide chemical starting points to explore metabolic intervention of the upstream enzyme GALK1 aimed at mitigating the GALT defect (substrate reduction).
Notes
This document represents version 3 of the TEP datasheet and includes all updates on the project as of October 2020. For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep
Files
GALT_GALK1_TEP_datasheet_v3.pdf
Files
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Additional details
Related works
- Is part of
- https://www.thesgc.org/tep (URL)
Funding
- A UK Hub to Catalyse Open Target Discovery. 106169
- Wellcome Trust