Multiple primary tumors in a young adult female (Li-Fraumeni syndrome)

The objectives of this study was to describe the occurrence of multiple primary tumors in a young adult as an example of the Li-Fraumeni syndrome and emphasize the difficulty and complexity of treatment. Young adult patients with multiple tumors are rarely reported. In our case, a 23-year-old female presented over a period of 14 months with primary tumors in the right adrenal, lung, breast and brain. She had a family history of lung cancer, breast cancer and astrocytoma grade II of the brain. The patient underwent resection of tumors of the right adrenal and left lower lung segment as well candidates for preventive bilateral mastectomy. Family history of cancer and the occurrence of multiple tumors at a young age should lead to suspicion of Li-Fraumeni Syndrome.