OVERVIEW OF FORMULATION AND DEVELOPMENT OF NANOSUSPENSION

Nanosuspensions are important carriers to develop novel drug formulations.  the drug research and development field, more or more new drug candidates has been found to be practically insoluble in aqueous solvents and many of them are simultaneously poorly soluble in a organic solvents Since nanosuspension drug delivery system (DDS) was firstly developed in 1994, nanosuspension DDS has attracted more & more attention as a formation solution for a poorly soluble drugs Nanosuspensions can be delivered by oral, parenteral, pulmonary or ocular routes. Nanosuspensions can also be used for targeted drug delivery when incorporated in theOcular inserts and mucoadhesive hydrogels. Currently, efforts are being directed to extending their applications in site-specific drug delivery. Nano refer to particles size range of 1–1000 nm. The reduction of drug particles into the submicron range leads to a significant increase in the dissolution rate and therefore enhances bioavailability. A nanosuspension not only solves the problems of poor solubility and bioavailability, but also alters the pharmacokinetics of drug and thus improves drug safety and efficacy. This review article describes the preparation methods, characterization, and applications of the nanosuspension.

Keyword: - Nanosuspension, soluble, bioavailability, drug delivery system, formation