КЛІТИННІ ФЕНОТИПИ ЗЛОЯКІСНИХ ПУХЛИН ШЛУНКА ЕПІТЕЛІАЛЬНОГО ПОХОДЖЕННЯ = CELLULAR PHENOTYPES OF MALIGNANT TUMORS OF THE STOMACH OF EPITELIAL ORIGIN

Mashukov A. O., Lurin A. G., Tkachenko O. I., Zgura O. M., Bilenko O. A., Ratsiborsky D. V., Merlich S.V., Shilin I.V., Maksimovsky V. E., Boychenko A. I., Sirbu V. M. CELLULAR PHENOTYPES OF MALIGNANT TUMORS OF THE STOMACH OF EPITELIAL ORIGIN. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2020;3(88):45-50. ISSN 0049-6804.

DOI http://dx.doi.org/10.5281/zenodo.4118651

http://www.herald.com.ua

УДК 616.33-006.6-089-076/-078

DOI http://dx.doi.org/10.5281/zenodo.4118651

КЛІТИННІ ФЕНОТИПИ ЗЛОЯКІСНИХ ПУХЛИН ШЛУНКА ЕПІТЕЛІАЛЬНОГО ПОХОДЖЕННЯ

А. О. Машуков1,2, А. Г. Лурін2, О. І. Ткаченко1, О. М. Згура2, О. А. Біленко1,

Д. В. Раціборський2, С. В. Мерліч2, І. В. Шілін2, В. Є. Максимовський1, А. І. Бойченко2,

В. М. Сирбу2

Одеський національний медичний університет1, Україна;

КНП «Одеський обласний онкологічний диспансер»2, Україна

CELLULAR PHENOTYPES OF MALIGNANT TUMORS OF THE STOMACH OF EPITELIAL ORIGIN

Mashukov A. O.1,2, Lurin A. G.2, Tkachenko O. I.1, Zgura O. M.2, Bilenko O. A.1, Ratsiborsky D. V.2, Merlich S. V.2 , Shilin I. V.2, Maksimovsky V. E.1, Boychenko A. I.2, Sirbu V. M.2

Odessa National Medical University1, Ukraine;

KNP "Odessa Regional Center for Oncology"2, Ukraine

mashukster@gmail.com

Summary

The aim: to study the effect of cell phenotype of gastric tumors on the survival of patients treated according to standard protocols. Object and methods of research. The work presents the results of a clinical study conducted on the basis of two medical institutions - the National Cancer Institute and the abdominal oncology surgery department of the Odessa Regional Oncology Center. 221 patients underwent surgery for gastric cancer (MS) from 2007 to 2013. The mean age of patients was 60.88 ± 10.5 years, men - 180, women - 41. All patients underwent surgery, performed 143 gastrectomies and 78 distal subtotal resections of the stomach. Results. All patients included in the study were radically operated. Tumors removed during surgery were examined using histological, cytological, immunohistochemical methods and genetic tests. The obtained research results are monitored for the presence / absence of clinical parallels and mathematical correlations between them. It is concluded that some combinations of immunohistochemical (IHC) markers are effective in separating groups of patients with different biology of gastric cancer. Survival of groups of patients was analyzed on the basis of analysis of molecular markers VEGFR, p53, Her2, Ki-67 and standard histological parameters (stage, degree of differentiation, etc.). The results obtained taking into account the survival and life expectancy in this category of patients allowed us to assess the feasibility and effectiveness of our proposed classification. Conclusions. More advanced surgeries, including D2 lymph dissection, were more effective in microsatellite-unstable and Epstein-Barr virus-associated gastric cancer.

Key words: gastric cancer, oncoproteins, immunohistochemical study, new classification.