Suggestions in the early diagnosis of preeclampsy

Preeclampsia remains a major issue discussed in contemporary obstetrics, and is considered to be responsible
for approximately 14% of estimated maternal deaths per year. The diagnosis is based on the monitoring of
maternal blood pressure, the presence of proteinuria and one or more characteristics: dysfunctions of the maternal
organs, including hepatic, renal, neurological, hematological and/or utero-placental dysfunction, these signs are nonspecific
and are generally present when preeclampsia is clinically manifest. In order to reduce the severe complications
caused by preeclampsia, a number of biochemical markers for predicting preeclampsia are described in the international
literature. Determining the serum level of angiogenic placental factors, in particular ET-1 (endothelin 1) and the PlGF
(placental growth factor) / sFlT-1 (soluble FMS-like tyrosine kinase-1) ratio, is very important in predicting preeclampsia
as early as possible, in order to avoid multiple complications for both the mother and the newborn.