Journal article Open Access
The Organoid Cell Atlas: A Rosetta Stone for Biomedical Discovery and Regenerative Therapy
Bock, Christoph;
Boutros, Michael;
Camp, J. Gray;
Clarke, Laura;
Clevers, Hans;
Knoblich, Juergen A.;
Liberali, Prisca;
Regev, Aviv;
Rios, Anne C.;
Stegle, Oliver;
Stunnenberg, Hendrik G.;
Teichmann, Sarah A.;
Treutlein, Barbara;
Vries, Robert G.J.
Human organoids – three-dimensional structures of cells that recapitulate important aspects of organ development in vitro – hold tremendous potential for biomedical applications. To help deliver on the promises of combining human organoids with single-cell technology, we have launched an Organoid Cell Atlas pilot project, as a ‘Biological Network’ within the Human Cell Atlas (HCA), focusing on single-cell profiling of organoids and in vitro cell models (https://www.humancellatlas.org/coordinators/). The Organoid Cell Atlas will foster the production, quality control, dissemination, and utilization of single-cell and spatial genomics data for human organoids, and it will connect such datasets with the comprehensive profiles of primary tissue that are being generated within the HCA. A first step toward establishing the Organoid Cell Atlas has recently been funded by the European Union Horizon 2020 call for “Pilot actions to build the foundations of a human cell atlas” through the “HCA|Organoid” project (http://hca-organoid.eu/). This preprint outlines the rationale for combining human organoids with single-cell technology and the concrete plans for established the Organoid Cell Atlas as a Rosetta Stone for biomedical discovery and regenerative therapy.
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- Publication date:
- August 30, 2020
- DOI:
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- Keyword(s):
- Organoids Single-cell profiling High-throughput imaging Multi-omics technology Data resources Bioinformatic tools Integrative analysis Biomedical applications
- License (for files):
- Creative Commons Attribution 4.0 International